Process engineering · optimization · scale-up

From a few grams in the flask to tonnes per year on the line.

We design, optimize, and scale supercritical CO₂ and subcritical water extraction processes for plant materials. Response-surface experimental design, full analytical support, and a fluent path from concept to a working production facility.

  • High-purity plant extracts, designed against your specification
  • In-house GC-MS, GC-FID and HPLC for every project
  • Turnkey delivery into the cosmetics, food, and pharmaceutical sectors
Operator loading a lab-scale supercritical CO2 extraction unit Analyst installing an HPLC column
RSM

Statistically-designed experiments for every extraction we touch.

GC · HPLC

Full in-house chromatography lab for identification and quantitation.

Turnkey

Lab to pilot to production, delivered with the SuperEx engineering team.

Process Development

An empirical, statistically-honest approach to process design.

Every project we take on runs through the same four phases. Most extraction failures we see in the field share a single cause: someone picked a pressure that sounded reasonable and locked in the recipe. We don't work that way.

01

Experimental design

A statistically valid design (typically Box-Behnken or central composite) probes pressure, temperature, flow, and co-solvent ratio with as few as 15–25 experiments.

02

Analytical fingerprint

Every extract is run on our GC-MS, GC-FID, and HPLC bench. Identification, quantitation, and impurity profile for every design point.

03

Multi-objective optimization

Yield, selectivity toward the target compound, and cost of manufacturing modelled together. The optimum is rarely the run with the highest yield.

04

Scale-up & confirmation

Lab-scale optima translated to pilot and industrial vessels using our in-house kinetic models, then confirmed in a hands-on production run.

Our full process development workflow
Flagship project · Turnkey

A complete extraction line for medicinal hemp, delivered ready to run.

Following Türkiye's September 2024 regulation enabling licensed production of hemp for active-ingredient extraction, we engineered a six-step turnkey process that takes fresh inflorescence in one end and pharmaceutical-grade CBD isolate out the other — with terpenes, seed oil, and protein meal as marketable co-products.

Per day · vessel size shown

What a single line produces.

Dried inflorescence processed
37.5 — 1250kg
Crude extract
5.6 — 187kg
Pure CBD isolate
2.0 — 67kg
Terpene fraction
0.6 — 20L
Total THC in product
< 0.3%
Production line vessel size
30 — 1000L
What else we do

Beyond CBD, the same toolkit applies to any plant material.

Volatile oils, oleoresins, pigments, polyphenols, alkaloids, fatty-acid complexes — we have published optimized extraction protocols for each. Browse the library below, or talk to us about a custom development project.

Selective fractionation

Multi-separator pressure-temperature programming to split essential oils, waxes, and oleoresins in a single SCF run.

Subcritical water (SWE)

Polar bioactives — pectins, anthocyanins, prenylflavonoids — that supercritical CO₂ cannot reach. CO₂-assisted hydrolysis where useful.

Kinetic modelling

In-house modelling of broken-and-intact-cell, shrinking-core, and desorption kinetics. Used to size industrial vessels with confidence.

Cost-of-manufacturing

Detailed CRM·CUT·COL·FMC breakdown with payback-period modelling at the chosen production vessel size.

Custom equipment

Together with our SuperEx engineering partners, we design and deliver bespoke SFE, SWE, and downstream processing systems.

Tech transfer

Documented standard operating procedures, operator training, and a confirmation production run on your installed equipment.